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I've paddled the Yukon a few times myself. Although we saw several canoe campers and a few First Nations fishing operations, we certainly were alone in the vastness of that wild river the majority of the time. But those mountains on either side sure do call out to you being as wild as can be. A hike most anywhere there would certainly take you far from any possible human contact.
Since we were racing each time, we did not have the opportunity to explore off river, and we camped short nights on gravel shoals. But while waiting out one afternoon thunderstorm, I walked just a bit back on the soft mushy moss muskeg. Very slow and difficult going. The mountain ridges would be much easier.